Mitochondrial Damage in the Trabecular Meshwork Occurs Only in Primary Open-Angle Glaucoma and in Pseudoexfoliative Glaucoma
نویسندگان
چکیده
منابع مشابه
Mitochondrial Damage in the Trabecular Meshwork Occurs Only in Primary Open-Angle Glaucoma and in Pseudoexfoliative Glaucoma
BACKGROUND Open-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment. Here, we report that, in fact, we have detected mitochondrial damage only in primary open-angle glaucoma and pseudo-exfoliation glaucoma, among several glaucoma types compared. METHODOLOGY/PRINCIPAL FINDINGS Mitochondr...
متن کاملGlycans of the trabecular meshwork in primary open angle glaucoma.
AIMS Glycan expression was compared in glaucomatous trabecular meshwork (TM) and normal TM in order to determine any differences which may reflect pathological changes underlying primary open angle glaucoma (POAG). METHODS Resin embedded TM from trabeculectomy specimens from 15 eyes with POAG and from 12 eyes with normal anterior segments were probed with a panel of biotinylated lectins and a...
متن کاملMitochondrial damage in the trabecular meshwork of patients with glaucoma.
OBJECTIVES To analyze the frequency of mitochondrial DNA (mtDNA) damage in patients with primary open-angle glaucoma. Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species. METHODS Mitochondrial damage was evaluated analyzing a ...
متن کاملserum homocysteine levels in pseudoexfoliative glaucoma and primary open angle glaucoma
purpose : to compare the serum homocysteine (hcy) level in healthy control individuals and in patient with primary open angle glaucoma (poag) and pseudoexfoliative glaucoma (pexg) methods : in this cross sectional study, 79 subjects including 36 patients with pexg, 23 patients with poag, and 20 matched healthy control individuals were recruited. those who used alcohol and mediations affecting h...
متن کاملSerum Homocysteine Levels in Pseudoexfoliative Glaucoma and Primary Open Angle Glaucoma
Purpose: To compare the serum homocysteine (Hcy) level in healthy control individuals and in patient with primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) Methods: In this cross sectional study, 79 subjects including 36 patients with PEXG, 23 patients with POAG, and 20 matched healthy control individuals were recruited. Those who used alcohol and mediations affecting Hcy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0014567